sábado, 21 de junio de 2014
miércoles, 11 de junio de 2014
Insulin Therapy for Type 2 Diabetes Mellitus
Insulin Therapy for Type 2 Diabetes Mellitus
The hemoglobin A1c target for most patients with type 2 diabetes is 7%
Ismail-Beigi et al: targed approximately 8%: Increased risk of hypoglycemia, reduced life expectancy,
extensive comorbidities (renal/liver failure- alcohol abuse), cardiovascular diseases, DM duration or reduced resources.
Insulin adverse effects include weight gain and hypoglycemia.
Basal insulin can be added to oral hypoglycemic agents (generally stopping sulfonylureas)
initially, and later, prandial insulin can be added in a stepwise fashion.
1. Insulin Resistance: impaired ability to suppress hepatic glucose production a peripheral glucose uptake.
2. Progressive imparirment of insulin secretion.
ACCORD HBA1c less than 6,0% more harmfull. 7,0-7.9 % less hypoglicemia and mortality.
DCCT/EDIC Increase in HBA1c from 7% to 8%. Results in an absolute increase from 1 event per year to only 2 events per year of retinopathy progression.
Lower HbA1c goals: younger, not developed hypoglycemia, and when the benefits of microvascular
disease protection outweigh the risks of hypoglycemia.
miércoles, 28 de mayo de 2014
EXTRASYSTOLE
KEY CONCEPTS OF VENTRICULAR PREMATURE BEATS.
VPB: PREMATURE ELECTRIC ACTIVITIE. Re-entry: Increase of aumatism. Ussually with constan coupling time(re-entry).
Exercise: to accelerate sinus rythm (overriding) VPB tend to disappear.
Coupling time: distance from a sinus beat qrs to ectopic qrs..
Compensatory pause: when the VPB activate the sinus node o AV node. reset this and generate an absolute refractory period in this cells, and when returnig to contract, the RR interval that includes VPB is twice than sinusal RR intervals.
The ventricular ES could reset the sinusal node and generate p wave and alterate the compensatory pause.
Morphology of extrasystole V1: right bundle branch block (QRS > +) originated in VI. Image LBBB QRS > - probably originated of right ventricle. Most positive in V1 morphology of RBBB. Most negative in V1 morphology of LBBB
Axis wave is more positive in superior wall. More negative originated in inferior wall.
Parasystole: cell group with own frequency (usually more slow). Entry block. opened output tract.
3 characteristic: variable coupling interval.
Interectopic long interval is multiple of interectopic short interval.
Fusion beat.
Ashman phenomenon: are described as wide complex QRS complexes that follow a short R-R interval preceded by a long R-R interval.This wide QRS complex typically has a right bundle branch block morphology and represents an aberrantly conducted complex that originates above the AV node, rather than a complex that originates in either the right or left ventricle.
R/T wave phenomenon.
SV VPB: P wave with different morpholgy of P sinusal. P originated in outup tract of right ventricle are negative in the inferior derivatives and positive in AVR.
auricular Extrasystole not conducted- Blockaded SV - ES.
Different morphology: multifocal VPB. worse pronostic.
VPB: PREMATURE ELECTRIC ACTIVITIE. Re-entry: Increase of aumatism. Ussually with constan coupling time(re-entry).
Exercise: to accelerate sinus rythm (overriding) VPB tend to disappear.
Coupling time: distance from a sinus beat qrs to ectopic qrs..
Compensatory pause: when the VPB activate the sinus node o AV node. reset this and generate an absolute refractory period in this cells, and when returnig to contract, the RR interval that includes VPB is twice than sinusal RR intervals.
The ventricular ES could reset the sinusal node and generate p wave and alterate the compensatory pause.
Morphology of extrasystole V1: right bundle branch block (QRS > +) originated in VI. Image LBBB QRS > - probably originated of right ventricle. Most positive in V1 morphology of RBBB. Most negative in V1 morphology of LBBB
Axis wave is more positive in superior wall. More negative originated in inferior wall.
Parasystole: cell group with own frequency (usually more slow). Entry block. opened output tract.
3 characteristic: variable coupling interval.
Interectopic long interval is multiple of interectopic short interval.
Fusion beat.
Ashman phenomenon: are described as wide complex QRS complexes that follow a short R-R interval preceded by a long R-R interval.This wide QRS complex typically has a right bundle branch block morphology and represents an aberrantly conducted complex that originates above the AV node, rather than a complex that originates in either the right or left ventricle.
R/T wave phenomenon.
SV VPB: P wave with different morpholgy of P sinusal. P originated in outup tract of right ventricle are negative in the inferior derivatives and positive in AVR.
auricular Extrasystole not conducted- Blockaded SV - ES.
Different morphology: multifocal VPB. worse pronostic.
martes, 27 de mayo de 2014
Beginnign the trip.
Hoy al enterarme que perdí la oportunidad de condonar mi crédito educativo para el Icetex. Decido crear este blog para acompañar mi camino a una Residencia médica en Medicina interna. A estudiar y a prepararme con todas las ganas el camino es largo y no es fácil pero es una prueba a enfrentar.
Me comprometo a mantener actualizado mi blog con datos útiles para repasos y enlaces de interés y apoyo.
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